Phenytoin Sodium, Prompt injection and Pseudoephedrine and Ibuprofen Suspension
Determining the interaction of Phenytoin Sodium, Prompt injection and Pseudoephedrine and Ibuprofen Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One case report has suggested that ibuprofen may cause phenytoin toxicity. However, data have been conflicting: one pharmacokinetic study did not demonstrate an effect and another study demonstrated that ibuprofen displaces phenytoin from protein binding sites in vitro. The clinical significance is unknown. Clinical and laboratory monitoring for altered phenytoin effect is recommended.
- Bachmann KA, Schwartz JI, Forney RB Jr, et al "Inability of ibuprofen to alter single dose phenytoin disposition." Br J Clin Pharmacol 21 (1986): 165-9
- Sandyk R "Phenytoin toxicity induced by interaction with ibuprofen." S Afr Med J 62 (1982): 592
- Dasgupta A, Timmerman TG "In vitro displacement of phenytoin from protein binding by nonsteroidal antiinflammatory drugs tolmetin, ibuprofen, and naproxen in normal and uremic sera." Ther Drug Monit 18 (1996): 97-9
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
Generic Name: ibuprofen / pseudoephedrine
Brand name: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Dimetapp Sinus, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Dayquil Pressure and Pain Caplet, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Dimetapp Childrens Cold & Fever, Children's Ibuprofen Cold Relief
Synonyms: Ibuprofen and pseudoephedrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Sodium, Prompt injection-Pseudoephedrine and triprolidine
- Phenytoin Sodium, Prompt injection-Pseudoephedrine Capsules and Tablets
- Phenytoin Sodium, Prompt injection-Pseudoephedrine Extended-Release Tablets (12 Hour)
- Phenytoin Sodium, Prompt injection-Pseudoephedrine Extended-Release Tablets (24 Hour)
- Phenytoin Sodium, Prompt injection-Pseudoephedrine Liquid
- Phenytoin Sodium, Prompt injection-Pseudoephedrine, Brompheniramine, and Codeine Liquid
- Pseudoephedrine and Ibuprofen Suspension-Phenytoin Suspension
- Pseudoephedrine and Ibuprofen Suspension-Philith
- Pseudoephedrine and Ibuprofen Suspension-Phillips Milk of Magnesia
- Pseudoephedrine and Ibuprofen Suspension-Phisohex
- Pseudoephedrine and Ibuprofen Suspension-Phl-Fluoxetine
- Pseudoephedrine and Ibuprofen Suspension-Phlemex