Phenytoin Sodium, Prompt injection and Rifadin IV Intravenous
Determining the interaction of Phenytoin Sodium, Prompt injection and Rifadin IV Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rifAMPin together with phenytoin may decrease the effects of phenytoin. Contact your doctor if your condition changes of if you experience loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Rifampin may induce the CYP450 hepatic metabolism of phenytoin. Plasma concentrations and clinical effects of phenytoin may be decreased.
MANAGEMENT: If rifampin and phenytoin must be used together, close observation for clinical and laboratory evidence of altered phenytoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control. It may be necessary to increase phenytoin dosage.
- Abajo FJ "Phenytoin interaction with rifampicin." Br Med J 297 (1988): 1048
- Kay L, Kampmann JP, Svedsen L, et al. "Influence of rifampicin and isoniazid on the kinetics of phenytoin." Br J Clin Pharmacol 20 (1985): 323-6
- Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
- Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
- Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
Generic Name: rifampin
Brand name: Rifadin IV, Rifadin, Rimactane
Synonyms: Rifadin IV (Intravenous), Rifadin IV
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Sodium, Prompt injection-Rifamate
- Phenytoin Sodium, Prompt injection-Rifampin
- Phenytoin Sodium, Prompt injection-Rifampin and Isoniazid
- Phenytoin Sodium, Prompt injection-Rifampin Capsules
- Phenytoin Sodium, Prompt injection-Rifampin Injection
- Phenytoin Sodium, Prompt injection-Rifampin Intravenous
- Rifadin IV Intravenous-Phenytoin Suspension
- Rifadin IV Intravenous-Philith
- Rifadin IV Intravenous-Phillips Milk of Magnesia
- Rifadin IV Intravenous-Phisohex
- Rifadin IV Intravenous-Phl-Fluoxetine
- Rifadin IV Intravenous-Phlemex