Phenytoin Sodium, Prompt injection and Simeprevir
Determining the interaction of Phenytoin Sodium, Prompt injection and Simeprevir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using simeprevir together with phenytoin is not recommended. Combining these medications may decrease the blood levels of simeprevir, which may reduce its effectiveness in treating hepatitis C. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent and some moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of simeprevir, which is primarily metabolized by the isoenzyme. In 18 healthy study subjects administered simeprevir (200 mg once daily) in combination with the potent CYP450 3A4 inducer rifampin (600 mg once daily) for 7 days, mean simeprevir peak plasma concentration (Cmax) increased by 31% but systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 48% and 92%, respectively. Likewise, when simeprevir (150 mg once daily) was given with the moderate inducer efavirenz (600 mg once daily) to 23 healthy subjects for 14 days, mean simeprevir Cmax, AUC and Cmin decreased by 51%, 71% and 91%, respectively. Simeprevir had no significant effects on the pharmacokinetics of efavirenz or rifampin, but increased the AUC of metabolite 25-desacetyl-rifampin by 24%.
MANAGEMENT: The use of simeprevir in combination with potent and some moderate CYP450 3A4 inducers such as carbamazepine, dexamethasone, efavirenz, enzalutamide, eslicarbazepine, etravirine, nevirapine, oxcarbazepine, phenobarbital, phenytoin, primidone, rifamycins, St. John's wort, and tipranavir should generally be avoided.
- "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals, Titusville, NJ.
- "Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Sodium, Prompt injection-Simethicone
- Phenytoin Sodium, Prompt injection-Simethicone Capsules and Tablets
- Phenytoin Sodium, Prompt injection-Simethicone Chewable Tablets
- Phenytoin Sodium, Prompt injection-Simethicone Liquid Drops
- Phenytoin Sodium, Prompt injection-Simethicone Oral Strips
- Phenytoin Sodium, Prompt injection-Simethicone Suspension
- Simeprevir-Phenytoin Suspension
- Simeprevir-Philith
- Simeprevir-Phillips Milk of Magnesia
- Simeprevir-Phisohex
- Simeprevir-Phl-Fluoxetine
- Simeprevir-Phlemex