Phenytoin Sodium, Prompt injection and Sucralfate Tablets
Determining the interaction of Phenytoin Sodium, Prompt injection and Sucralfate Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sucralfate together with phenytoin may decrease the effects of phenytoin. Separate phenytoin at least two hours before or 6 hours after sucralfate and contact your doctor if loss of seizure control occurs. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor
Professional:ADJUST DOSING INTERVAL: Sucralfate may interfere with the absorption of oral phenytoin and may reduce its therapeutic effect. Sucralfate may interact in a similar way with other oral hydantoins.
MANAGEMENT: Patients should be advised to take phenytoin at least two hours before or 6 hours after sucralfate and to notify their physician if loss of seizure control occurs.
- McCarthy DM "Sucralfate." N Engl J Med 325 (1991): 1017-25
- "Product Information. Carafate (sucralfate)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- Smart HL, Somerville KW, Williams J, et al "The effects of sucralfate upon phenytoin absorption in man." Br J Clin Pharmacol 20 (1985): 238-40
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
Generic Name: sucralfate
Brand name: Carafate
Synonyms: Sucralfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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