Phenytoin Sodium, Prompt injection and Zidovudine Oral Solution
Determining the interaction of Phenytoin Sodium, Prompt injection and Zidovudine Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has suggested that zidovudine may have variable effects on plasma phenytoin levels. Increased levels, decreased levels, and no change have been reported. If zidovudine and phenytoin must be used together, close observation for altered clinical and laboratory effects is recommended.
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Phenytoin (PH) monitoring in HIV(+) individuals: is there an interaction with zidovudine (ZDV)?" Int Conf AIDS 9 (1993): 504
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Zidovudine (oral/injection), Zidovudine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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