Phenytoin Suspension and Zovirax (Acyclovir Capsules and Tablets)
Determining the interaction of Phenytoin Suspension and Zovirax (Acyclovir Capsules and Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking phenytoin, tell your doctor if you also use acyclovir. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect phenytoin levels in your body. You should notify your doctor if your seizure control changes or worsens. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: A case report suggests that plasma phenytoin concentrations may be decreased in the presence of acyclovir. Seizure activity may increase. The mechanism is unknown. A similar interaction may theoretically occur with other hydantoins.
MANAGEMENT: The clinician should consider closer clinical and laboratory monitoring if acyclovir therapy is started or stopped in the presence of phenytoin. The dose of phenytoin should be adjusted as clinically indicated. Patients should be advised to report loss of seizure control.
- Parmeggiani A, Riva R, Posar A, Rossi PG "Possible interaction between acyclovir and antiepileptic treatment." Ther Drug Monit 17 (1995): 312-5
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
Generic Name: acyclovir
Brand name: Sitavig, Zovirax
Synonyms: Zovirax
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Phenytoin Suspension-Zovirax (Acyclovir Cream)
- Phenytoin Suspension-Zovirax (Acyclovir Injection)
- Phenytoin Suspension-Zovirax (Acyclovir Ointment)
- Phenytoin Suspension-Zovirax (Acyclovir Suspension)
- Phenytoin Suspension-Zovirax Cream
- Phenytoin Suspension-Zovirax Injection
- Zovirax (Acyclovir Capsules and Tablets)-Philith
- Zovirax (Acyclovir Capsules and Tablets)-Phillips Milk of Magnesia
- Zovirax (Acyclovir Capsules and Tablets)-Phisohex
- Zovirax (Acyclovir Capsules and Tablets)-Phl-Fluoxetine
- Zovirax (Acyclovir Capsules and Tablets)-Phlemex
- Zovirax (Acyclovir Capsules and Tablets)-Phlemex Forte