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Phillips Milk of Magnesia and Promethazine VC

Determining the interaction of Phillips Milk of Magnesia and Promethazine VC and the possibility of their joint administration.

Check result:

Phillips Milk of Magnesia <> Promethazine VC

Relevance: 06.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with aluminum- or magnesium-containing antacids may decrease the serum concentrations of orally administered phenothiazines. The proposed mechanism is antacid adsorption resulting in reduced phenothiazine bioavailability. The interaction has been reported for chlorpromazine but may occur with other phenothiazines. In a study of ten patients treated with chlorpromazine, 30 mL of an antacid containing aluminum and magnesium hydroxide reduced the urinary excretion of chlorpromazine by 10% to 45%. In another study with six psychiatric patients, coadministration of chlorpromazine oral suspension with 30 mL of an antacid containing aluminum hydroxide and magnesium trisilicate resulted in a 20% reduction in serum chlorpromazine level two hours later. The clinical significance is unknown. Psychiatric relapse occurred in a chlorpromazine-treated patient following the addition of antacid therapy according to a single case report. Separating the times of administration by 2 to 3 hours may help if an interaction is suspected.

References

Forrest FM, Forrest IS, Serra MT "Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients." Biol Psychiatry 2 (1970): 53-8
Fann WE "Interactions of psychotropic drugs in the elderly." Postgrad Med 53 (1973): 182-6
Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
Fann WE, Davis JM, Janowsky DS, Sekerke HJ, Schmidt DM "Chlorpromazine: effects of antacids on its gastrointestinal absorption." J Clin Pharmacol 13 (1973): 388-90
Romankiewicz JA "Effects of antacids on gastrointestinal absorption of drugs." Prim Care 3 (1976): 537-50

Phillips Milk of Magnesia

Generic Name: magnesium hydroxide

Brand name: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia, Dulcolax Milk of Magnesia, Concentrated Phillips Milk of Magnesia

Synonyms: n.a.

What is Phillips Milk of Magnesia?

Promethazine VC

Generic Name: phenylephrine / promethazine

Brand name: Promethazine VC, Phenergan VC, Promethazine VC Plain

Synonyms: n.a.

What is Promethazine VC?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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