Physostigmine and Timolol Eye Drops (Bottle)
Determining the interaction of Physostigmine and Timolol Eye Drops (Bottle) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using physostigmine and timolol ophthalmic together can lower your blood pressure and slow your heart rate. This can cause a slow heartbeat, headaches, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor
Professional:MONITOR: Severe bradycardia and hypotension may develop during concomitant administration of some beta-blockers and anticholinesterase agents. The mechanism is unknown but may involve additive effects. Data have been conflicting. Some studies have reported no significant changes.
MANAGEMENT: The patient's hemodynamic status should be monitored during coadministration. Patients should be advised to notify their physician if they experience syncope, orthostasis, or a slow pulse.
- Eldor J, Hoffman B, Davidson JT "Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol." Anaesthesia 42 (1987): 1294-7
Generic Name: physostigmine
Brand name: Antilirium
Synonyms: n.a.
Generic Name: timolol ophthalmic
Brand name: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE, Timoptic
Synonyms: Timolol ophthalmic, Timolol (Ophthalmic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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