Physostigmine Injection and Vanaclear PD
Determining the interaction of Physostigmine Injection and Vanaclear PD and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using triprolidine together with physostigmine. Medications like triprolidine may reduce the effectiveness of physostigmine. In addition, patients with Alzheimer's disease or other dementia may be more likely to experience nervous system side effects of triprolidine such as drowsiness, confusion, and mental impairment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Due to opposing effects, agents that possess anticholinergic activity (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; class IA antiarrhythmics especially disopyramide; carbamazepine; cimetidine; ranitidine) may negate the already small pharmacologic benefits of acetylcholinesterase inhibitors in the treatment of dementia. These agents may also adversely affect elderly patients in general. Clinically significant mental status changes associated with anticholinergic agents can range from mild cognitive impairment to delirium, and patients with Alzheimer's disease and other dementia are especially sensitive.
MANAGEMENT: Drugs that possess anticholinergic activity should generally be avoided in patients with Alzheimer's disease or other cognitive impairment, regardless of whether they are receiving an acetylcholinesterase inhibitor. For patients requiring treatment to counteract adverse effects of acetylcholinesterase inhibitor therapy (e.g., gastrointestinal intolerance, urinary problems), an agent without anticholinergic properties should be used whenever possible. Otherwise, a dosage reduction, slower titration, or even discontinuation of the acetylcholinesterase inhibitor should be considered. For patients who are already receiving an acetylcholinesterase inhibitor with anticholinergic agents, every attempt should be made to discontinue the latter or substitute them with less anticholinergic alternatives. Caution is required, however, since anticholinergic withdrawal may occur. Seizures have been reported following abrupt discontinuation of anticholinergics during acetylcholinesterase inhibitor therapy.
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- Roe CM, Anderson MJ, Spivack B "Use of anticholinergic medications by older adults with dementia." J Am Geriatr Soc 50 (2002): 836-42
- Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH "Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts." Arch Intern Med 163 (2003): 2716-2724
- Carnahan RM, Lund BC, Perry PJ, Chrischilles EA "The concurrent use of anticholinergics and cholinesterase inhibitors: rare event or common practice?" J Am Geriatr Soc 52 (2004): 2082-7
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Generic Name: physostigmine
Brand name: Antilirium
Synonyms: Physostigmine
Generic Name: triprolidine
Brand name: Histex, M-Hist PD, Vanaclear PD, Vanahist PD, Zymine, Zymine XR, Tripohist, Histex Syrup, Histex PD Drops, Histex PDX
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Physostigmine Injection-Vanacof
- Physostigmine Injection-Vanacof CD
- Physostigmine Injection-Vanacof DM
- Physostigmine Injection-Vanacof G
- Physostigmine Injection-Vanacof-8
- Physostigmine Injection-Vanadom
- Vanaclear PD-Physostigmine Ophthalmic
- Vanaclear PD-Physostigmine Salicylate
- Vanaclear PD-Phytonadione
- Vanaclear PD-Phytonadione Injection
- Vanaclear PD-Phytonadione oral/injection
- Vanaclear PD-Phytonadione Orally Disintegrating Tablets