Pilocarpine Hydrochloride and Tezacaftor/ivacaftor and ivacaftor

• Generic Name: pilocarpine ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Pilocar, Pilopine-HS, Pilostat, Isopto Carpine, Adsorbocarpine, Pilagan with C Cap, Ocu-Carpine, Ocusert, Piloptic-1/2, Piloptic-1, Akarpine, Piloptic-2, Piloptic-3, Piloptic-4, Piloptic-6

Symptomatic treatment of radiation-induced dry mouth (xerostomia) in patients with head and neck cancer.

Symptomatic treatment of dry mouth in patients with Sjögren syndrome.

There are few comparative studies of pilocarpine and cevimeline (a similar muscarinic agonist). Although both drugs can increase salivary flow and improve symptoms of dry mouth, adverse effects may differ based on differences in selectivity and affinity for muscarinic receptors. (See Actions.)

• Generic Name: ivacaftor / tezacaftor
• Dosage Forms: n.a.
• Other Brand Names: Symdeko, Symdeko 4-Week

Tezacaftor/ivacaftor and ivacaftor combination is used to treat cystic fibrosis (CF) in patients 12 years of age and older. It is only used for patients who have two copies of F508del mutation, or who have at least one mutation in their CF transmembrane conductance regulator (CFTR) gene. Your doctor will use a test to check for the mutation before you receive the medicine.

Tezacaftor/ivacaftor and ivacaftor is available only with your doctor's prescription.