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Pimozide and Sertraline Tablets

Determining the interaction of Pimozide and Sertraline Tablets and the possibility of their joint administration.

Check result:

Pimozide <> Sertraline Tablets

Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pimozide together with sertraline is not recommended. Combining these medications can increase the blood levels of pimozide to dangerous levels and cause an irregular heart rhythm that may be serious and potentially life-threatening. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with pimozide. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration with sertraline may increase the plasma concentrations of pimozide. The mechanism of interaction has not been established. In 15 healthy volunteers, administration of a single 2 mg dose of pimozide during sertraline treatment 200 mg/day resulted in 35% and 37% increases in mean pimozide peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of pimozide alone. While these increases were not associated with significant prolongation of the QTc interval (>=15% from baseline) in the study subjects, the effect of sertraline on pimozide given at dosages greater than a single 2 mg dose is not currently known. The use of pimozide has been associated with dose-related prolongation of the QT interval, thus elevated plasma levels may potentiate the risk of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death. Moreover, sertraline itself has been associated with rare cases of QT prolongation and torsade de pointes during postmarketing use, thus an additive pharmacodynamic effect with pimozide may occur as well.

MANAGEMENT: Given the narrow therapeutic index of pimozide and the potential for interaction with sertraline, concomitant administration of these agents is considered contraindicated.

References

Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6
Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98
"Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
"Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.
Alderman J "Coadministration of sertraline with cisapride or pimozide: an open-label, nonrandomized examination of pharmacokinetics and corrected QT intervals in healthy adult volunteers." Clin Ther 27 (2005): 1050-63
Pacher P, Kecskemeti V "Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?" Curr Pharm Des 10 (2004): 2463-75
Desta Z, Soukhova N, Flockhart DA "In Vitro Inhibition of Pimozide N-Dealkylation by Selective Serotonin Reuptake Inhibitors and Azithromycin." J Clin Psychopharmacol 22 (2002): 162-168
Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82

Pimozide

Generic Name: pimozide

Brand name: Orap

Synonyms: n.a.

What is Pimozide?

Sertraline Tablets

Generic Name: sertraline

Brand name: Zoloft

Synonyms: Sertraline

What is Sertraline Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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