Pioglitazone and metformin and Rifampin
Determining the interaction of Pioglitazone and metformin and Rifampin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with rifampin may increase the gastrointestinal absorption and therapeutic efficacy of metformin. The mechanism may involve rifampin-mediated induction of the organic cation transporter 1 (OCT1) in the gastrointestinal tract. MANAGEMENT: Until more information is available, caution is advised if rifampin and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosage of metformin may be adjusted as necessary. References Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with rifampin may increase the gastrointestinal absorption and therapeutic efficacy of metformin. The mechanism may involve rifampin-mediated induction of the organic cation transporter 1 (OCT1) in the gastrointestinal tract.
MANAGEMENT: Until more information is available, caution is advised if rifampin and metformin are used concomitantly. Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosage of metformin may be adjusted as necessary.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: metformin / pioglitazone
Brand name: Actoplus Met, Actoplus Met XR
Synonyms: Metformin and pioglitazone, Pioglitazone and Metformin
Generic Name: rifampin
Brand name: Rifadin, Rifadin IV, Rimactane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pioglitazone and metformin-Rifampin and Isoniazid
- Pioglitazone and metformin-Rifampin Capsules
- Pioglitazone and metformin-Rifampin Injection
- Pioglitazone and metformin-Rifampin Intravenous
- Pioglitazone and metformin-Rifampin Oral, Intravenous
- Pioglitazone and metformin-Rifampin, Isoniazid, and Pyrazinamide
- Rifampin-Pioglitazone and Metformin Extended-Release Tablets
- Rifampin-Pioglitazone and Metformin Tablets
- Rifampin-Pioglitazone Hydrochloride
- Rifampin-Pioglitazone Tablets
- Rifampin-Piperacillin
- Rifampin-Piperacillin and tazobactam