Pioglitazone and Metformin Extended-Release Tablets and Trospium Chloride
Determining the interaction of Pioglitazone and Metformin Extended-Release Tablets and Trospium Chloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:MetFORMIN may reduce the blood levels and effects of trospium. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with metformin may decrease the plasma concentrations of trospium. The mechanism of interaction has not been established. In 44 healthy subjects, administration of trospium chloride extended-release 60 mg once daily in combination with metformin immediate-release 500 mg twice daily reduced the steady-state mean trospium peak plasma concentration (Cmax) by 34% and systemic exposure (AUC) by 29%. The clinical relevance of these changes is unknown. Whether metformin at higher dosages may have a greater effect on trospium pharmacokinetics has not been investigated. Trospium chloride did not significantly affect the steady-state pharmacokinetics of metformin.
MANAGEMENT: Patients should be monitored for potentially diminished efficacy of trospium chloride during coadministration with metformin.
- "Product Information. Sanctura (trospium chloride)." Odyssey Pharmaceutical, East Hanover, NJ.
Generic Name: metformin / pioglitazone
Brand name: Actoplus Met, Actoplus Met XR
Synonyms: Metformin and pioglitazone, Pioglitazone and Metformin
Generic Name: trospium
Brand name: Sanctura, Sanctura XR, Regurin
Synonyms: Trospium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pioglitazone and Metformin Extended-Release Tablets-Trospium Chloride Capsules
- Pioglitazone and Metformin Extended-Release Tablets-Trospium Extended-Release Capsules
- Pioglitazone and Metformin Extended-Release Tablets-Trospium Tablets
- Pioglitazone and Metformin Extended-Release Tablets-Trovan
- Pioglitazone and Metformin Extended-Release Tablets-Troxyca ER
- Pioglitazone and Metformin Extended-Release Tablets-TRUEplus
- Trospium Chloride-Pioglitazone and Metformin Tablets
- Trospium Chloride-Pioglitazone Hydrochloride
- Trospium Chloride-Pioglitazone Tablets
- Trospium Chloride-Piperacillin
- Trospium Chloride-Piperacillin and tazobactam
- Trospium Chloride-Piperacillin and tazobactam Intravenous