Pioglitazone Hydrochloride and Rilonacept

• Generic Name: pioglitazone
• Dosage Forms: n.a.
• Other Brand Names: Actos

Used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise to improve glycemic control in patients with type 2 (noninsulin-dependent) diabetes mellitus (NIDDM). Should be added to, not substituted for, other antidiabetic agents in patients whose NIDDM is not adequately controlled by these agents.

May be added to glyburide/metformin fixed combination therapy if hyperglycemia is not adequately controlled with the fixed combination. May be used in combination with repaglinide if hyperglycemia is not adequately controlled with diet, exercise, and monotherapy with another oral antidiabetic agent.

Not effective as sole therapy for type 1 diabetes mellitus or diabetic ketoacidosis.

• Generic Name: rilonacept
• Dosage Forms: n.a.
• Other Brand Names: Arcalyst

Rilonacept is used to treat some of the symptoms of rare genetic conditions such as Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS).

FCAS and MWS are inflammatory disorders in which the body develops certain symptoms without a known cause (such as virus, bacteria, or illness). These symptoms include fever, chills, fatigue, and joint pain. More serious symptoms may involve the bones and joints, the central nervous system (deafness, vision loss, mental impairment), or major organs such as the kidneys.

Rilonacept may treat or prevent the symptoms of Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS). However, this medication is not a cure for these inherited conditions.

Rilonacept may also be used for purposes not listed in this medication guide.