Piperacillin Sodium and Tazobactam Sodium and Rocuronium Intravenous
Determining the interaction of Piperacillin Sodium and Tazobactam Sodium and Rocuronium Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using rocuronium together with piperacillin can prolong the effects of rocuronium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of piperacillin. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in support of an interaction between piperacillin and vecuronium. In contrast, a randomized controlled trial involving thirty patients undergoing abdominal operations reported no clinically important prolongation of vecuronium-induced muscle relaxation when piperacillin or cefoxitin was administered pre- or intra-operatively. The clinical significance and the extent to which other nondepolarizing muscle relaxants may interact remains unclear.
MANAGEMENT: Close observation for profound and prolonged respiratory depression and muscle weakness is recommended if these drugs must be used together.
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Generic Name: piperacillin / tazobactam
Brand name: Zosyn
Synonyms: Piperacillin and tazobactam, Piperacillin and Tazobactam
Generic Name: rocuronium
Brand name: Zemuron
Synonyms: Rocuronium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Piperacillin Sodium and Tazobactam Sodium-Rogaine
- Piperacillin Sodium and Tazobactam Sodium-Rogaine (Minoxidil Topical Foam)
- Rocuronium Intravenous-Piperazine
- Rocuronium Intravenous-Pipracil
- Rocuronium Intravenous-Piqray
- Rocuronium Intravenous-Piqray 200MG Daily Dose
- Rocuronium Intravenous-Piqray 250MG Daily Dose
- Rocuronium Intravenous-Piqray 300MG Daily Dose