Piperazine and Thorazine (Chlorpromazine Tablets)
Determining the interaction of Piperazine and Thorazine (Chlorpromazine Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlorproMAZINE together with piperazine may cause seizures. Watch for seizure activity and if a seizures occurs contact your doctor immediately. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: A case report has suggested that piperazine may provoke seizures in patients being treated with chlorpromazine. The mechanism is unknown. Controlled clinical studies are needed to definitively document this interaction.
MANAGEMENT: The patient should be closely observed for seizure activity and if a seizure occurs, this interaction may be suspected.
- Boulos BM, Davis LE "Hazard of simultaneous administration of phenothiazine and piperazine." N Engl J Med 280 (1969): 1245-6
Generic Name: chlorpromazine
Brand name: Thorazine, Ormazine, Thorazine Spansule
Synonyms: Thorazine (Injection), Thorazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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