Pirfenidone and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels of pirfenidone, which may make the medication less effective in treating your condition. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 1A2 or other isoenzymes involved in the metabolism of pirfenidone such as CYP450 2C9 and 2C19 may significantly decrease the plasma concentrations of pirfenidone. Loss of therapeutic efficacy may result, as pirfenidone is primarily (70% to 80%) metabolized by CYP450 1A2, with minor contribution from CYP450 2C9, 2C19, 2D6, and 2E1. Following a single 801 mg oral dose of pirfenidone in 25 smokers and 25 healthy nonsmokers, the Cmax and AUC of pirfenidone in smokers were 68% and 46% of those in nonsmokers, respectively. Cigarette smoke is a known inducer of CYP450 1A2.

MANAGEMENT: Potent inducers of CYP450 1A2, 2C9, and/or 2C19 such as phenytoin, carbamazepine, and rifampin should be discontinued prior to the initiation of pirfenidone and avoided during therapy.

Pirfenidone

Generic Name: pirfenidone

Brand name: Esbriet

Synonyms: n.a.

What is Pirfenidone?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?