Pitolisant Hydrochloride and Tylenol Cold & Flu Severe
Determining the interaction of Pitolisant Hydrochloride and Tylenol Cold & Flu Severe and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available. MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Professional:MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available.
MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Generic Name: pitolisant
Brand name: Wakix
Synonyms: Pitolisant
Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine
Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pitolisant Hydrochloride-Tylenol Cold Head Congestion (Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine Caps & Tabs)
- Pitolisant Hydrochloride-Tylenol Cold Head Congestion (Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine Caps & Tabs)
- Pitolisant Hydrochloride-Tylenol Cold Multi Symptom
- Pitolisant Hydrochloride-Tylenol Cold Multi-Symptom (Acetaminophen, Dextromethorphan, and Phenylephrine Liquid)
- Pitolisant Hydrochloride-Tylenol Cold Multi-Symptom (Acetaminophen, Doxylamine, Dextromethorphan, and Phenylephrine Liquid)
- Pitolisant Hydrochloride-Tylenol Cold Multi-Symptom (Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine Caps & Tabs)
- Tylenol Cold & Flu Severe-Pitressin
- Tylenol Cold & Flu Severe-Pitressin Injection
- Tylenol Cold & Flu Severe-Pitressin Synthetic
- Tylenol Cold & Flu Severe-Placidyl
- Tylenol Cold & Flu Severe-Plan B
- Tylenol Cold & Flu Severe-Plan B One-Step