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Plaquenil and Rasuvo

Determining the interaction of Plaquenil and Rasuvo and the possibility of their joint administration.

Check result:
Plaquenil <> Rasuvo
Relevance: 19.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A small, single dose pharmacokinetic study has indicated that coadministration of methotrexate and chloroquine may lead to a reduced bioavailability of methotrexate. Clinical evidence of this effect has not been established. Consider monitoring the patient more closely for reduced efficacy and adjust the dose of methotrexate if needed.

References
  • Seideman P, Albertioni F, Beck O, Eksborg S, Peterson C "Chloroquine reduces the bioavailability of methotrexate in patients with rheumatoid arthritis - a possible mechanism of reduced hepatotoxicity." Arthritis Rheum 37 (1994): 830-3
Plaquenil

Generic Name: hydroxychloroquine

Brand name: Plaquenil, Quineprox

Synonyms: n.a.

Rasuvo

Generic Name: methotrexate

Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep

Synonyms: Rasuvo (injection), Rasuvo Injection

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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