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Platinol-AQ and Plazomicin Intravenous

Determining the interaction of Platinol-AQ and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Platinol-AQ <> Plazomicin Intravenous

Relevance: 08.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Plazomicin can sometimes cause kidney damage, and using it with CISplatin may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you experience some or all of these problems during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Combining cisplatin and aminoglycosides may increase the risk of renal toxicity. Both cisplatin and aminoglycosides have been reported to cause renal magnesium wasting. The exact mechanism of the interaction is unknown.

MANAGEMENT: In patients currently receiving cisplatin therapy, the use of less nephrotoxic antimicrobials is preferable. If cisplatin and an aminoglycoside must be used together, renal function and serum magnesium should be monitored carefully.

References

"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Blachley JD, Hill JB "Renal and electrolyte disturbances associated with cisplatin." Ann Intern Med 95 (1981): 628-32
Hass A, Anderson L, Lad T "The influence of aminoglycosides on the nephrotoxicity of cis-diamminedichlorophatinum in cancer patients." J Infect Dis 147 (1983): 363
Christensen ML, Stewart CF, Crom WR "Evaluation of aminoglycoside disposition in patients previously treated with cisplatin." Ther Drug Monit 11 (1989): 631-6
Patel R, Savage A "Symptomatic hypomagnesemia associated with gentamicin therapy." Nephron 23 (1979): 50-2
Dentino M, Luft FC, Yum MN, et al "Long term effect of cis-diamminedichloride platinum (CDDP) on renal function and structure in man." Cancer 41 (1978): 1274-81
Stewart CF, Christensen ML, Crom WR, Evans WE "The effect of cisplatin therapy on gentamicin pharmacokinetics." Drug Intell Clin Pharm 18 (1984): 512

Platinol-AQ

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: Platinol-AQ (Intravenous)

What is Platinol-AQ?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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