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Platinol-AQ and Proglycem (Diazoxide Capsules)

Determining the interaction of Platinol-AQ and Proglycem (Diazoxide Capsules) and the possibility of their joint administration.

Check result:

Platinol-AQ <> Proglycem (Diazoxide Capsules)

Relevance: 08.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Hypotensive agents such as diazoxide may alter renal function and increase the nephrotoxic effects of cisplatin. At this time, one known case of nephrotoxicity has occurred in a patient receiving diazoxide concurrently with other antihypertensives and cisplatin. No dosage alterations are currently recommended. This combination should be used with caution, and renal function should be monitored.

References

Markman M, Trump DL "Nephrotoxicity with cisplatin and antihypertensive medications." Ann Intern Med 96 (1982): 257

Platinol-AQ

Generic Name: cisplatin

Brand name: Platinol, Platinol-AQ

Synonyms: Platinol-AQ (Intravenous)

What is Platinol-AQ?

Proglycem (Diazoxide Capsules)

Generic Name: diazoxide

Brand name: Proglycem, Hyperstat

Synonyms: Proglycem

What is Proglycem (Diazoxide Capsules)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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