Plavix and Xtandi

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using enzalutamide together with clopidogrel. Combining these medications can significantly increase the blood levels and effects of enzalutamide. This may increase the risk and/or severity of side effects such seizure, tiredness, weakness, diarrhea, muscle or bone pain, hot flushes, swelling, tingling or prickling sensation, headache, dizziness, insomnia, anxiety, and high blood pressure. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 2C8 may significantly increase the plasma concentrations of enzalutamide, which is primarily metabolized by the isoenzyme. In healthy volunteers, administration of a single 160 mg oral dose of enzalutamide following multiple oral doses of the potent CYP450 2C8 inhibitor gemfibrozil resulted in a 2.2-fold increase in the composite systemic exposure (AUC) of enzalutamide plus its pharmacologically active metabolite, N-desmethyl enzalutamide, compared to administration of enzalutamide alone. There was minimal effect on the peak plasma concentration (Cmax) of enzalutamide plus N-desmethyl enzalutamide.

MANAGEMENT: The use of enzalutamide in combination with potent CYP450 2C8 inhibitors such as gemfibrozil should generally be avoided. If concomitant use is required, a reduction of the enzalutamide dosage to 80 mg once daily is recommended. Following discontinuation of the potent CYP450 2C8 inhibitor, the enzalutamide dosage should be returned to that used prior to initiation of the inhibitor.

Plavix

Generic Name: clopidogrel

Brand name: Plavix

Synonyms: n.a.

What is Plavix?

Xtandi

Generic Name: enzalutamide

Brand name: Xtandi

Synonyms: n.a.

What is Xtandi?