Drug search by name

Plazomicin Intravenous and Specimen Collection Kit

Determining the interaction of Plazomicin Intravenous and Specimen Collection Kit and the possibility of their joint administration.

Check result:

Plazomicin Intravenous <> Specimen Collection Kit

Relevance: 17.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Plazomicin can cause hearing loss, ringing in the ears, vertigo, and kidney problems, and combining it with certain diuretics like furosemide may increase the risks. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of parenteral or inhaled aminoglycoside antibiotics or oral neomycin in combination with loop diuretics may potentiate the risk of oto- or nephrotoxicity due to additive or synergistic pharmacologic effects of these drugs and or altered aminoglycoside serum and tissue levels. Coadministration of aminoglycosides with intravenous mannitol may increase the risk of nephrotoxicity. The risk may be greater with high dosages of either drug, preexisting renal insufficiency, advanced age, dehydration, or the presence of other oto- or nephrotoxic drugs. The onset of ototoxicity may be greatly delayed, and cochlear damage may initially be asymptomatic. Reversible and irreversible hearing losses have been reported with aminoglycosides and loop diuretics.

MANAGEMENT: The use of aminoglycoside antibiotics in combination with loop diuretics or intravenous mannitol should generally be avoided. Renal function tests and serial, vestibular, and audiometric tests should be performed as appropriate for the type of diuretic before and during therapy if coadministration is necessary.

References

Quick CA, Hoppe W "Permanent deafness associated with furosemide administration." Ann Otol Rhinol Laryngol 84 (1975): 94-101
Whiting PH, Barber HE, Petersen J "The effect of frusemide and piretanide on the renal clearance of gentamicin in man." Br J Clin Pharmacol 12 (1981): 795-9
Bates DE, Beaumont SJ, Baylis BW "Ototoxicity induced by gentamicin and furosemide." Ann Pharmacother 36 (2002): 446-51
Bruun JN, Eng J, Arnesen AR "Tobramycin therapy of serious infections." Scand J Infect Dis 13 (1981): 59-64
Moore RD, Smith CR, Lipsky JJ "Risk factors for nephrotoxicity in patients treated with aminoglycosides." Ann Intern Med 100 (1984): 352-7
"Product Information. Tobi tobramycin solution for inhalation (tobramycin)" PathoGenesis, Skokie, IL.
Tilstone WJ, Semple PF, Lawson DH, Boyle JA "Effects of furosemide on glomerular filtration rate and clearance of practolol, digoxin, cephaloridine, and gentamicin." Clin Pharmacol Ther 22 (1977): 389-94
Smith CR, Lietman PS "Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans." Antimicrob Agents Chemother 23 (1983): 133-7
Lawson DH, Tilstone WJ, Gray JM, Srivastava PK "Effect of furosemide on the pharmacokinetics of gentamicin in patients." J Clin Pharmacol 22 (1982): 254-8
Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61
"Product Information. Lasix (furosemide)." sanofi-aventis , Bridgewater, NJ.
Meriwether WD, Mangi RJ, Serpick AA "Deafness following standard intravenous dose of ethacrynic acid." JAMA 216 (1971): 795-8
Schentag JJ, Cerra FB, Plaut ME "Clinical and pharmacokinetic characteristics of aminoglycoside nephrotoxicity in 201 critically ill patients." Antimicrob Agents Chemother 21 (1982): 721-6
Lynn AM, Redding GJ, Morray JP, Tyler DC "Isolated deafness following recovery from neurologic injury and adult respiratory distress syndrome. A sequela of intercurrent aminoglycoside and diuretic use." Am J Dis Child 139 (1985): 464-6
Athlin L, Domellof L, Holm S "Gentamicin treatment in severe surgical infections: serum levels, interactions, toxicity and efficacy." Acta Chir Scand 147 (1981): 225-30
"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Salamy A, Eldredge L, Tooley WH "Neonatal status and hearing loss in high-risk infants." J Pediatr 114 (1989): 847-52
Kaka JS, Lyman C, Kilarski DJ "Tobramycin-furosemide interaction." Drug Intell Clin Pharm 18 (1984): 235-8
Mathog RH, Klein WJ "Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia." N Engl J Med 280 (1969): 1223-4

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

Specimen Collection Kit

Generic Name: furosemide

Brand name: Lasix, Diaqua-2, Lo-Aqua

Synonyms: Furosemide

What is Specimen Collection Kit?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions