Pneumococcal Polysaccharide Vaccine (23-Valent) and Zostavax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pneumococcal 23-polyvalent vaccine may interfere with the immune response to zoster vaccine live. These vaccines should generally not be given at the same time. A person who has been vaccinated with pneumococcal 23-polyvalent vaccine should generally wait at least 4 weeks before getting zoster vaccine live, and vice versa. The immunizing doctor should be informed of recent vaccination history so that appropriate measures and/or precautions can be taken. It is important to tell the doctor about all other medications being used, including vitamins and herbs. Do not stop using any medications without first talking to the doctor.

ADJUST DOSING INTERVAL: Concomitant administration of pneumococcal 23-valent vaccine may reduce the immunogenicity of varicella-zoster virus (VZV) vaccine. The mechanism of interaction has not been described. In a randomized, double-blind, controlled clinical trial consisting of 473 adults sixty years of age or older, VZV antibody levels were significantly lower in the subjects who received both vaccines concurrently than in those who were given VZV vaccine four weeks after the pneumococcal 23-valent vaccine. At four weeks postvaccination, VZV antibody geometric mean titers were 338 gpELISA units/mL for the concomitant group and 484 gpELISA units/mL for the sequential group (GMT ratio = 0.70).

MANAGEMENT: Varicella-zoster virus vaccine and pneumococcal 23-valent vaccine should not be given concurrently. If possible, these vaccines should be administered at least four weeks apart.

Pneumococcal Polysaccharide Vaccine (23-Valent)

Generic Name: pneumococcal 23-polyvalent vaccine

Brand name: Pneumovax 23

Synonyms: Pneumococcal polysaccharides vaccine (PPSV), 23-valent

What is Pneumococcal Polysaccharide Vaccine (23-Valent)?

Zostavax

Generic Name: zoster vaccine live

Brand name: Zostavax

Synonyms: n.a.

What is Zostavax?