Poly-Tussin AC and Propranolol Injection
Determining the interaction of Poly-Tussin AC and Propranolol Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Propranolol and codeine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
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- Rodriguez de la Torre B, Dreher J, Malevany I, et al. "Serum levels and cardiovascular effects of tricyclic antidepressants and selective serotonin reuptake inhibitors in depressed patients." Ther Drug Monit 23 (2001): 435-40
- Pacher P, Kecskemeti V "Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?" Curr Pharm Des 10 (2004): 2463-75
- Andrews C, Pinner G "Postural hypotension induced by paroxetine." BMJ 316 (1998): 595
Generic Name: brompheniramine / codeine / phenylephrine
Brand name: M-End PE, Poly-Tussin AC, TL-Hist CD
Synonyms: n.a.
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: Propranolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Poly-Tussin AC-Propranolol Intravenous
- Poly-Tussin AC-Propranolol Oral Solution
- Poly-Tussin AC-Propranolol Oral Solution (Hemangeol)
- Poly-Tussin AC-Propranolol Sustained-Release Bead Capsules
- Poly-Tussin AC-Propranolol Sustained-Release Capsules
- Poly-Tussin AC-Propranolol Tablets
- Propranolol Injection-Poly-Tussin DM
- Propranolol Injection-Poly-Tussin EX Syrup
- Propranolol Injection-Poly-Tussin HD
- Propranolol Injection-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)
- Propranolol Injection-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Tablets and Capsules)
- Propranolol Injection-Poly-Vent IR