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Polyethylene Glycol-Electrolyte Solution and Bisacodyl and Zide

Determining the interaction of Polyethylene Glycol-Electrolyte Solution and Bisacodyl and Zide and the possibility of their joint administration.

Check result:

Polyethylene Glycol-Electrolyte Solution and Bisacodyl <> Zide

Relevance: 22.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using hydroCHLOROthiazide together with any kind of medication that has a laxative effect. Combining these medications, especially over a prolonged period, may increase the risk of dehydration and electrolyte abnormalities. In severe cases, dehydration and electrolyte abnormalities can lead to irregular heart rhythm, seizures, and kidney problems. You should use bisacodyl exactly as prescribed by your doctor or as directed on the label of the medication. Contact your doctor if you experience potential signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, muscle cramps, decreased urination, palpitation, and increased heart rate. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes, including sodium, potassium, magnesium and zinc, and these effects may be additive to those of diuretics.

MANAGEMENT: In general, laxatives should only be used on a short-term, intermittent basis in recommended dosages. During concomitant use with diuretics, patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia. If maintenance of bowel regularity is required, patients should be advised to exercise and increase fiber in the diet and/or consider the use of bulk-forming laxatives.

References

Blumenthal M, Goldberg A, Brinckmann J, eds. "Herbal Medicine: Expanded Commission E Monographs." Newton, MA: Integrative Medicine Communications (2000):
Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45
Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61
Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8
Atsmon J, Dolev E "Drug-induced hypomagnesaemia : scope and management." Drug Saf 28 (2005): 763-88

Polyethylene Glycol-Electrolyte Solution and Bisacodyl

Generic Name: bisacodyl / polyethylene glycol 3350 / potassium chloride / sodium bicarbonate / sodium chloride

Brand name: Half Lytely and Bisacodyl Lemon Lime, HalfLytely and Bisacodyl, HalfLytely and Bisacodyl with Flavor Packs, GaviLyte-H and Bisacodyl with Flavor Packs

Synonyms: Bisacodyl and polyethylene glycol (PEG) 3350 with electrolytes

What is Polyethylene Glycol-Electrolyte Solution and Bisacodyl?

Zide

Generic Name: hydrochlorothiazide

Brand name: Aquazide H, HydroDIURIL, Microzide,

Synonyms: HCTZ, Hydrochlorothiazide

What is Zide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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