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Posaconazole Tablets and Reglan (Metoclopramide Injection Solution)

Determining the interaction of Posaconazole Tablets and Reglan (Metoclopramide Injection Solution) and the possibility of their joint administration.

Check result:

Posaconazole Tablets <> Reglan (Metoclopramide Injection Solution)

Relevance: 12.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Metoclopramide may decrease the blood levels and effects of posaconazole. Contact your doctor if your condition worsens or you develop new infections during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with metoclopramide may decrease the plasma concentrations of posaconazole. The proposed mechanism is reduced absorption of posaconazole due to increases in gastric motility induced by metoclopramide. In 12 study subjects who received a single 400 mg dose of posaconazole oral suspension with a liquid nutritional supplement, posaconazole mean peak plasma concentration (Cmax) and systemic exposure (AUC) were reduced by approximately 20% during coadministration with metoclopramide (10 mg three times a day for 2 days). The clinical significance is unknown, but reduced antifungal efficacy is possible.

MANAGEMENT: Caution is advised if posaconazole is prescribed in combination with metoclopramide. Patients should be monitored for the development of breakthrough fungal infections.

References

Krishna G, Moton A, Ma L, Malavade D, Medlock M, McLeod J "Effect of gastric pH, dosing regimen and prandial state, food and meal timing relative to dose, and gastro-intestinal motility on absorption and pharmacokinetics of the antifungal posaconazole." 18th European Congress of Clinical Microbiology and Infectious Diseases April (2008): 20
"Product Information. Noxafil (posaconazole)." Schering-Plough Corporation, Kenilworth, NJ.

Posaconazole Tablets

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Posaconazole, Posaconazole (oral/injection)

What is Posaconazole Tablets?

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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