Pralidoxime and Succinylcholine Chloride Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pralidoxime may reduce the effects of succinylcholine. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Oximes used in organophosphorous poisoning such as pralidoxime or obidoxime may antagonize the neuromuscular blocking effects of succinylcholine and mivacurium. Oximes reactivate acetylcholinesterase that has been inactivated by phosphorylation due to exposure to an organophosphorous nerve agent or insecticide, and the reactivated acetylcholinesterase then hydrolyzes excess acetylcholine resulting from the exposure to help restore impaired cholinergic neural function. Since succinylcholine and mivacurium are metabolized by plasma cholinesterases, patients with organophosphorous poisoning who have been treated with an oxime may exhibit accelerated reversal of the neuromuscular blocking effects of these agents relative to those who have not received an oxime.

MANAGEMENT: Neuromuscular effects should be monitored when succinylcholine or mivacurium is coadministered with an oxime.

Pralidoxime

Generic Name: pralidoxime

Brand name: Protopam Chloride

Synonyms: n.a.

What is Pralidoxime?

Succinylcholine Chloride Injection

Generic Name: succinylcholine

Brand name: Anectine, Quelicin

Synonyms: Succinylcholine

What is Succinylcholine Chloride Injection?