Pramipexole Dihydrochloride and Xeljanz XR

• Generic Name: pramipexole
• Dosage Forms: n.a.
• Other Brand Names: Mirapex, Mirapex ER

Symptomatic management of idiopathic parkinsonian syndrome.

Used as an adjunct to levodopa for the symptomatic management of parkinsonian syndrome in patients with advanced disease.

Also used as monotherapy for the initial symptomatic management of parkinsonian syndrome. Most clinicians would use levodopa for initial therapy in individuals >70 years of age (less likely than younger individuals to develop levodopa-related motor complications and because of concerns about cognitive dysfunction), in patients with cognitive impairment, and in those with severe disease. A dopamine receptor agonist may be preferred for initial therapy in patients ≤70 years of age.

Symptomatic management of moderate-to-severe primary restless legs syndrome (Ekbom syndrome).

• Generic Name: tofacitinib
• Dosage Forms: n.a.
• Other Brand Names: Xeljanz, Xeljanz XR

Xeljanz XR is used to treat moderate to severe rheumatoid arthritis or active psoriatic arthritis in adults who have tried methotrexate or other medications without successful treatment of symptoms. This medicine is sometimes given in combination with methotrexate or other arthritis medicines.

Xeljanz XR is also used to treat moderate to severe ulcerative colitis in adults who cannot use certain other medications, or after other treatments have failed. Extended-release this medicine (Xeljanz XR) is not for use in treating ulcerative colitis.

Xeljanz XR may also be used for purposes not listed in this medication guide.