Praziquantel and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using praziquantel together with secobarbital. Combining these medications may decrease the blood levels of praziquantel and make it ineffective or less effective in treating your condition. Your doctor may be able to prescribe an alternative to praziquantel that you can take with secobarbital, or you may need to discontinue secobarbital for some time before you begin taking praziquantel. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with CYP450 inducers may decrease the plasma concentrations of praziquantel. In a crossover study with a 2-week washout period, plasma praziquantel concentrations were undetectable in 7 out of 10 subjects who ingested a single 40 mg/kg dose of praziquantel following pretreatment with the potent CYP450 inducer rifampin (600 mg orally daily for 5 days). When the same dose of praziquantel was administered two weeks after discontinuation of rifampin, the mean praziquantel peak plasma concentration (Cmax) and systemic exposure (AUC) were 35% and 23% lower, respectively, than when praziquantel was given alone. The extent to which other, less potent CYP450 inducers may interact with praziquantel is unknown.

MANAGEMENT: The use of praziquantel in combination with CYP450 inducers should generally be avoided, since therapeutically effective blood levels of praziquantel may not be achieved. Alternative agents for schistosomiasis should be considered whenever possible in patients receiving treatment with a CYP450 inducer.

Praziquantel

Generic Name: praziquantel

Brand name: Biltricide

Synonyms: n.a.

What is Praziquantel?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?