Premarin (Conjugated Estrogens Tablets) and Tegsedi

• Generic Name: conjugated estrogens
• Dosage Forms: tablet, film coated
• Other Brand Names: Enjuvia, Premarin, Premarin Intravenous, Cenestin

• It is used to add estrogen to the body when the ovaries have been taken out or do not work the right way.
• It is used to put off soft, brittle bones (osteoporosis) in women after change of life.
• It is used to prevent or lower the signs of the change of life (menopause).
• Rarely, it is used to treat breast or prostate cancers.
• It may be given to you for other reasons. Talk with the doctor.

• Generic Name: inotersen
• Dosage Forms: injection, solution
• Other Brand Names: Tegsedi

Tegsedi (inotersen) works by decreasing a protein called transthyretin (TTR, made primarily in the liver). Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare condition in which abnormal deposits of TTR protein build up in many parts of the body, interfering with normal function.

Tegsedi injection is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hATTR. This medicine can help reduce symptoms such as pain, numbness, tingling, abnormal heartbeats, diarrhea, constipation, weakness, and problems with movement in your arms or legs.

Tegsedi is available only from a certified pharmacy under a special program.