Premarin Vaginal and Rocuronium Bromide Injection

• Generic Name: conjugated estrogens topical
• Dosage Forms: vaginal cream
• Other Brand Names:

  Premarin Vaginal Cream, Premarin Vaginal, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens-A

Premarin Vaginal Cream contains a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Premarin Vaginal Cream is used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Premarin Vaginal may also be used for purposes not listed in this medication guide.

• Generic Name: rocuronium
• Dosage Forms: injection
• Other Brand Names: Zemuron

Production of skeletal muscle relaxation during surgery after general anesthesia has been induced.

Facilitation of endotracheal intubation (rapid sequence and routine tracheal intubation).

Also has been used to facilitate mechanical ventilation in the ICU; however, manufacturer states that prolonged use in this setting has not been evaluated. Whenever neuromuscular blocking agents are used in the ICU, consider benefits versus risks of such therapy and assess patients frequently to determine need for continued paralysis. (See Intensive Care Setting under Cautions.)

Compared with other neuromuscular blocking agents, rocuronium has a rapid onset and intermediate duration of action. Recommended as an alternative to succinylcholine for rapid sequence intubation. When given in sufficient doses (e.g., ≥1 mg/kg), produces similar intubating conditions to succinylcholine.