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Prestalia and Probalan

Determining the interaction of Prestalia and Probalan and the possibility of their joint administration.

Check result:

Prestalia <> Probalan

Relevance: 04.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may decrease the renal clearance of ACE inhibitors. Plasma levels and antihypertensive effects of ACE inhibitors may be increased. Data are available for captopril only. Although no adverse effects have been reported in study subjects, the patient's blood pressure should be monitored during coadministration.

References

Drummer OH, Thompson J, Hooper R, Jarrott B "Effect of probenecid on the disposition of captopril and captopril dimer in the rat." Biochem Pharmacol 34 (1985): 3347-51
Singhvi SM, Duchin KL, Willard DA, et al "Renal handling of captopril: effect of probenecid." Clin Pharmacol Ther 32 (1982): 182-9

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

Probalan

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probalan?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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