Prestalia and Rifabutin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Rifabutin may significantly reduce the blood levels of amLODIPine, which may make the medication ineffective or less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of calcium channel blockers, the majority of which are primarily metabolized by the isoenzyme. Undetectable plasma levels have been reported for some calcium blockers when given orally.

MANAGEMENT: Concomitant use of calcium channel blockers with potent CYP450 3A4 inducers should generally be avoided. However, if concomitant use is necessary, dosage adjustments as well as close monitoring of pharmacologic effects, particularly blood pressure, should be considered whenever a potent CYP450 3A4 inducer is added to or withdrawn from therapy.

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?