Pretomanid Tablets and Sacubitril and valsartan
Determining the interaction of Pretomanid Tablets and Sacubitril and valsartan and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pretomanid may significantly increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic anion transporter 3 (OAT3). The proposed mechanism, based on in vitro data, is decreased clearance due to pretomanid-mediated inhibition of OAT3. No clinical interaction studies have been conducted in humans with OAT3 substrates. MANAGEMENT: Caution is advised if pretomanid is used concomitantly with drugs that are substrates of OAT3, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring of the OAT3 substrate drug should be considered whenever pretomanid is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects. References "Product Information. Pretomanid (pretomanid)." The Global Alliance for TB Drug Development, New York, NY.
Professional:MONITOR: Coadministration with pretomanid may significantly increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of organic anion transporter 3 (OAT3). The proposed mechanism, based on in vitro data, is decreased clearance due to pretomanid-mediated inhibition of OAT3. No clinical interaction studies have been conducted in humans with OAT3 substrates.
MANAGEMENT: Caution is advised if pretomanid is used concomitantly with drugs that are substrates of OAT3, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring of the OAT3 substrate drug should be considered whenever pretomanid is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
- "Product Information. Pretomanid (pretomanid)." The Global Alliance for TB Drug Development, New York, NY.
Generic Name: pretomanid
Brand name:
Synonyms: Pretomanid
Generic Name: sacubitril / valsartan
Brand name: Entresto
Synonyms: Sacubitril and Valsartan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pretomanid Tablets-Safetussin CD
- Pretomanid Tablets-Safetussin DM
- Pretomanid Tablets-Safetussin PM
- Pretomanid Tablets-Safinamide
- Pretomanid Tablets-Safinamide Mesylate
- Pretomanid Tablets-Safyral
- Sacubitril and valsartan-Pretz-D
- Sacubitril and valsartan-Prevacid
- Sacubitril and valsartan-Prevacid 24 HR
- Sacubitril and valsartan-Prevacid Injection
- Sacubitril and valsartan-Prevacid Naprapac
- Sacubitril and valsartan-Prevacid OTC