Prevacid Injection and Sympazan
Determining the interaction of Prevacid Injection and Sympazan and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lansoprazole may increase the blood levels and effects of cloBAZam. This may increase the risk and/or severity of side effects such as drowsiness, tiredness, drooling, constipation, and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of clobazam with inhibitors of CYP450 2C19 may significantly increase the plasma concentrations of its active metabolite, N-desmethylclobazam, which is primarily metabolized by the isoenzyme. Based on extrapolation from pharmacogenomic data, inhibition of CYP450 2C19 may result in up to a 5-fold increase in exposure to N-desmethylclobazam. At therapeutic dosages of clobazam, plasma concentrations of N-desmethylclobazam are 3 to 5 times higher than those of the parent compound. Based on animal and in vitro receptor binding data, estimates of the relative potency of N-desmethylclobazam compared to parent compound range from 1/5 to equal potency.
MANAGEMENT: Dosage adjustment of clobazam may be necessary when coadministered with strong (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate (e.g., omeprazole) inhibitors of CYP450 2C19.
- "Product Information. Onfi (clobazam)." Lundbeck Inc, Deerfield, IL.
Generic Name: lansoprazole
Brand name: FIRST Lansoprazole, Prevacid, Prevacid OTC, Prevacid SoluTab
Synonyms: Prevacid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Prevacid Injection-Symproic
- Prevacid Injection-Symtuza
- Prevacid Injection-Synalar
- Prevacid Injection-Synalar (Fluocinolone Cream and Ointment)
- Prevacid Injection-Synalar (Fluocinolone Solution)
- Prevacid Injection-Synalar Mild
- Sympazan-Prevacid Naprapac
- Sympazan-Prevacid OTC
- Sympazan-Prevacid SoluTab
- Sympazan-Prevalite
- Sympazan-Preven EC
- Sympazan-Prevex Hc Topical application