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Prevacid SoluTab and Theo-Dur

Determining the interaction of Prevacid SoluTab and Theo-Dur and the possibility of their joint administration.

Check result:

Prevacid SoluTab <> Theo-Dur

Relevance: 27.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Lansoprazole may cause a minor decrease in the area under the plasma concentration-time curve of theophylline and related drugs. This effect appears to be small (approximately a 13% decrease in one study) and may be related either to a reduction in absorption or to enhanced clearance caused by induction of hepatic enzymes by lansoprazole. Dosage adjustment is not believed to be necessary. However, close observation for evidence of altered methylxanthine effect is recommended.

References

Kokufu T, Ihara N, Sugioka N, Koyama H, Ohta T, Mori S, Nakajima K "Effects of lansoprazole on pharmacokinetics and metabolism of theophylline." Eur J Clin Pharmacol 48 (1995): 391-5
Granneman GR, Karol MD, Locke CS "Pharmacokinetic interaction between lansoprazole and theophylline." Ther Drug Monit 17 (1995): 460-4
"Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
Ko JW, Jang IJ, Shin JG, Nam SK, Shin SG, Flockhart DA "Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers." Clin Pharmacol Ther 65 (1999): 606-14

Prevacid SoluTab

Generic Name: lansoprazole

Brand name: FIRST Lansoprazole, Prevacid, Prevacid OTC, Prevacid SoluTab

Synonyms: n.a.

What is Prevacid SoluTab?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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