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Prevpac and Reyataz (Atazanavir Capsules)

Determining the interaction of Prevpac and Reyataz (Atazanavir Capsules) and the possibility of their joint administration.

Check result:

Prevpac <> Reyataz (Atazanavir Capsules)

Relevance: 07.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using atazanavir together with lansoprazole is not recommended. By reducing stomach acid, lansoprazole can decrease the absorption and blood levels of atazanavir and make the medication less effective against HIV. Your doctor or pharmacist may be able to offer suggestions on safer alternatives if you require treatment for stomach acid or ulcer while you are being treated with atazanavir. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent use of proton pump inhibitors may decrease the oral bioavailability of atazanavir and substantially reduce its concentrations in plasma. Atazanavir solubility decreases with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of proton pump inhibitors is not recommended in treatment-experienced patients receiving atazanavir with or without ritonavir or cobicistat. In treatment-naive patients receiving atazanavir with ritonavir or cobicistat, it is recommended that the dose of the proton-pump inhibitor not exceed 20 mg/day of omeprazole, or equivalent, and doses should be separated by 12 hours. Atazanavir without ritonavir or cobicistat should not be coadministered with proton pump inhibitors in treatment-naive patients.

References

"Drug interactions. Atazanavir and acid-reducing agents." TreatmentUpdate 18 (2006): 4
Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9
"Product Information. Evotaz (atazanavir-cobicistat)." Bristol-Myers Squibb, Princeton, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Ray JE, Marriott D, Bloch MT, McLachlan AJ "Therapeutic drug monitoring of atazanavir: surveillance of pharmacotherapy in the clinic." Br J Clin Pharmacol 60 (2005): 291-9
"Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0

Prevpac

Generic Name: amoxicillin / clarithromycin / lansoprazole

Brand name: Prevpac

Synonyms: n.a.

What is Prevpac?

Reyataz (Atazanavir Capsules)

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Reyataz

What is Reyataz (Atazanavir Capsules)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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