Prilosec and Valdecoxib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with valdecoxib or its prodrug, parecoxib, may increase the plasma concentrations of omeprazole. The mechanism is valdecoxib inhibition of CYP450 2C19 and 3A4, the isoenzymes responsible for the metabolic clearance of omeprazole. According to product labeling, coadministration of valdecoxib (40 mg twice a day) and omeprazole (40 mg once a day) resulted in a 46% increase in the systemic exposure (AUC) of omeprazole compared to administration of omeprazole alone. The pharmacokinetics of valdecoxib were not significantly affected. Because higher dosages (up to 360 mg/day) of omeprazole are tolerated in Zollinger-Ellison patients, no dosage adjustment for omeprazole is indicated at normally recommended dosages. However, drugs whose absorption is sensitive to pH (e.g., some cephalosporins such as cefditoren, cefpodoxime, and cefuroxime; antiretroviral agents including atazanavir, delavirdine, and fosamprenavir; cyanocobalamin; ketoconazole; enteric coated preparations) may be negatively impacted by concomitant administration of omeprazole and valdecoxib or parecoxib. Coadministration of valdecoxib with dosages of omeprazole higher than 40 mg/day has not been studied.

Prilosec

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Prilosec, Prilosec OTC, Zegerid>

Synonyms: n.a.

What is Prilosec?

Valdecoxib

Generic Name: valdecoxib

Brand name:

Synonyms: Valdecoxib (Oral)

What is Valdecoxib?