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Prilosec (Omeprazole Delayed-Release Capsules) and Tolazamide

Determining the interaction of Prilosec (Omeprazole Delayed-Release Capsules) and Tolazamide and the possibility of their joint administration.

Check result:

Prilosec (Omeprazole Delayed-Release Capsules) <> Tolazamide

Relevance: 13.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some benzimidazole proton pump inhibitors may increase sulfonylurea concentrations, and hypoglycemic effects may be increased. The mechanism may be inhibition of CYP450 2C19 and/or 3A4 hepatic metabolism. The clinical significance of this interaction is unknown. Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.

References

Toon S, Holt BL, Mullins FGP, Khan A "Effects of cimetidine, ranitidine and omeprazole on tolbutamide pharmacokinetics." J Pharm Pharmacol 47 (1995): 85-8
Humphries TJ "Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole." Dig Dis Sci 36 (1991): 1665-9
"Product Information. Nexium (esomeprazole)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.
"Product Information. Prilosec (omeprazole)." Merck & Co, Inc, West Point, PA.

Prilosec (Omeprazole Delayed-Release Capsules)

Generic Name: omeprazole

Brand name: FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, Prilosec, Prilosec OTC, Prilosec, Prilosec OTC, Zegerid>

Synonyms: Prilosec

What is Prilosec (Omeprazole Delayed-Release Capsules)?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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