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Primaxin IV and Valcyte

Determining the interaction of Primaxin IV and Valcyte and the possibility of their joint administration.

Check result:

Primaxin IV <> Valcyte

Relevance: 24.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using imipenem together with valGANciclovir. Combining these medications can increase the risk of seizures. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: According to the product labeling for ganciclovir and imipenem-cilastatin, generalized seizures have occurred in patients receiving these agents together. The mechanism has not been described, but these agents are individually epileptogenic and may have additive effects on seizure threshold during coadministration.

MANAGEMENT: The manufacturers recommend that concomitant use of ganciclovir or its prodrug, valganciclovir, with imipenem-cilastatin be avoided unless the potential benefits outweigh the risks. Patients receiving this combination should be closely monitored for tremors, mental status changes, and seizures.

References

"Product Information. Cytovene (ganciclovir)." Genentech, South San Francisco, CA.
"Product Information. Primaxin (imipenem-cilastatin)." Merck & Company Inc, West Point, PA.

Primaxin IV

Generic Name: cilastatin / imipenem

Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage

Synonyms: n.a.

What is Primaxin IV?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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