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Probenecid and Xanax

Determining the interaction of Probenecid and Xanax and the possibility of their joint administration.

Check result:

Probenecid <> Xanax

Relevance: 23.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited clinical evidence suggests that benzodiazepine effects may have a more rapid onset and be more prolonged when probenecid is used concurrently. The mechanism may be related to interference with hepatic benzodiazepine conjugation. The clinical significance is unknown. Patients should be monitored for prolonged or excessive CNS depression. Benzodiazepine dosage reductions may be necessary.

References

Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51
Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9

Probenecid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Probenecid?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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