Probenecid and colchicine and Xanax XR Oral
Determining the interaction of Probenecid and colchicine and Xanax XR Oral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited clinical evidence suggests that benzodiazepine effects may have a more rapid onset and be more prolonged when probenecid is used concurrently. The mechanism may be related to interference with hepatic benzodiazepine conjugation. The clinical significance is unknown. Patients should be monitored for prolonged or excessive CNS depression. Benzodiazepine dosage reductions may be necessary.
- Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51
- Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9
Generic Name: colchicine / probenecid
Brand name:
Synonyms: Probenecid and colchicine (Oral)
Generic Name: alprazolam
Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol
Synonyms: Xanax XR
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Probenecid and colchicine-XaQuil XR
- Probenecid and colchicine-Xarelto
- Probenecid and colchicine-Xarelto Starter Pack
- Probenecid and colchicine-Xartemis XR
- Probenecid and colchicine-Xartemix XR
- Probenecid and colchicine-Xatmep
- Xanax XR Oral-Probenecid Tablets
- Xanax XR Oral-Probiotic Formula (Bacillus Coagulans)
- Xanax XR Oral-Probucol
- Xanax XR Oral-Probuphine
- Xanax XR Oral-Procainamide
- Xanax XR Oral-Procainamide capsules