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Probenecid and colchicine and Zyprexa

Determining the interaction of Probenecid and colchicine and Zyprexa and the possibility of their joint administration.

Check result:

Probenecid and colchicine <> Zyprexa

Relevance: 18.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with probenecid may increase the plasma concentrations of olanzapine. The mechanism is probenecid inhibition of olanzapine glucuronidation via uridine diphosphoglucuronate-glucuronosyltransferase (UGT1A4). In 12 healthy volunteers, probenecid (500 mg orally twice a day) started one day before olanzapine administration (5 mg single dose) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of olanzapine by 18% and 26%, respectively, compared to administration of olanzapine alone. The clinical significance of this interaction and the effect during long-term administration is unknown.

References

Markowitz JS, Devane CL, Liston HL, Boulton DW, Risch SC "The effects of probenecid on the disposition of risperidone and olanzapine in healthy volunteers." Clin Pharmacol Ther 71 (2002): 30-8

Probenecid and colchicine

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Probenecid and colchicine (Oral)

What is Probenecid and colchicine?

Zyprexa

Generic Name: olanzapine

Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv

Synonyms: n.a.

What is Zyprexa?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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