Probenecid Tablets and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with probenecid may increase the metabolism of carbamazepine to carbamazepine 10,11-epoxide. The proposed mechanism is induction of CYP450 3A4 and 2C8 activities by probenecid. In 10 healthy volunteers, pretreatment with probenecid (500 mg orally twice daily for 10 days) resulted in a 19% decrease in the area under the plasma concentration-time curve (AUC) of carbamazepine (200 mg single oral dose on day 6) compared to placebo, while AUC of carbamazepine 10,11-epoxide increased 33% by probenecid relative to placebo. Probenecid also increased the oral clearance of carbamazepine by 26% and the AUC ratio of the epoxide metabolite to carbamazepine by 45%. The clinical significance of these changes is unknown.

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probenecid Tablets?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?