Drug search by name

Probenecid Tablets and Zidovudine oral/injection

Determining the interaction of Probenecid Tablets and Zidovudine oral/injection and the possibility of their joint administration.

Check result:

Probenecid Tablets <> Zidovudine oral/injection

Relevance: 19.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using zidovudine together with probenecid may increase the effects of zidovudine. Contact your doctor if you experience nausea, vomiting, drowsiness, fever, rash, headache, or weakness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Probenecid inhibits the renal excretion and glucuronidation of zidovudine, and serum zidovudine levels may be increased. The patient may be exposed to a greater risk of zidovudine toxicity.

MANAGEMENT: Patients should be monitored for signs of zidovudine toxicity (anemia, nausea, headache, myalgia, malaise, fever, or rash). Zidovudine dosage may need to be reduced, or the dosing interval may need to be lengthened.

References

Kornhauser DM, Hendrix CW, Nerhood LJ, et al "Probenecid and zidovudine metabolism." Lancet 2 (1989): 473-5
de Miranda P, Good SS, Yarchoan R, et al "Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex." Clin Pharmacol Ther 46 (1989): 494-500
Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probenecid Tablets?

Zidovudine oral/injection

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine oral/injection?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions