Probenecid Tablets and Zosyn

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Probenecid may increase the blood levels of tazobactam. This can increase the risk of side effects such as diarrhea, nausea, vomiting, and upset stomach. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with probenecid may increase and prolong the serum concentrations of tazobactam. The mechanism is competitive inhibition by probenecid of the renal tubular secretion of tazobactam via OAT1 and OAT3. A one gram oral dose of probenecid reduced the clearance of tazobactam (administered by injection in combination with piperacillin) by approximately 20% to 25% and prolonged its half-life by 71%. The peak plasma concentration was not affected.

MANAGEMENT: Although the clinical relevance of this interaction has not been established, caution may be advisable when probenecid must be used with tazobactam-containing preparations. The product labeling for piperacillin-tazobactam recommends avoiding concomitant use with probenecid unless the benefit outweighs the risk.

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probenecid Tablets?

Zosyn

Generic Name: piperacillin / tazobactam

Brand name: Zosyn

Synonyms: n.a.

What is Zosyn?