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Procanbid and Quin-G

Determining the interaction of Procanbid and Quin-G and the possibility of their joint administration.

Check result:
Procanbid <> Quin-G
Relevance: 13.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with procainamide can increase the levels of procainamide and can affect the rhythm of your heart. Contact your doctor if you experience tiredness, dizziness, fainting, low blood pressure, confusion, tremor, difficulty breathing, and an irregular heartbeat. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Limited clinical data suggest that quinidine may significantly increase serum levels and half-life of procainamide. The mechanism may be related quinidine-induced reduction in the renal clearance of procainamide. Increased procainamide serum concentrations may result in ECG changes such as QRS widening or prolonged QT interval and increased risk of arrhythmias such as torsades de pointes.

MANAGEMENT: Until more data are available, quinidine and procainamide should generally not be administered concurrently unless benefit to the patient outweighs risk. If these two drugs are given together, serum procainamide and NAPA levels, and ECG changes and hemodynamic status should be closely monitored. Patients should be advised to promptly notify their physician if they experience drowsiness, dizziness, syncope, confusion, tremor, or palpitations.

References
  • Saal K, Werner J, Greene L, et al "Effect of amiodarone on serum quinidine and procainamide levels." Am J Cardiol 53 (1984): 1264-7
  • Highes B, Dyer J, Schwartz A "Increased procainamide plasma concentration caused by quinidine: a new drug interaction." Am Heart J 114 (1987): 908-9
Procanbid

Generic Name: procainamide

Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: n.a.

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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