Procarbazine and Xatmep

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using methotrexate together with procarbazine. Both medications can be harmful to the kidneys, and these effects are increased when the medications are used together. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Three cases of renal impairment have been reported following the combined use of high dose methotrexate and procarbazine (despite adequate standard precautions such as hydration and alkalinization of the urine). The specific mechanism of this interaction has not been reported. However, it has been theorized that procarbazine has a transient effect on kidneys, which alters the excretion of methotrexate. If high dose methotrexate is administered before recovery from this change, methotrexate excretion is delayed and subsequent prolonged exposure of the kidneys to methotrexate may result in further impairment of renal function.

MANAGEMENT: An interval of at least 72 hours is recommended between administration of the final dose of procarbazine and the beginning of high dose methotrexate administration.

Procarbazine

Generic Name: procarbazine

Brand name: Matulane

Synonyms: n.a.

What is Procarbazine?

Xatmep

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: n.a.

What is Xatmep?