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Prochlorperazine and Thiopental

Determining the interaction of Prochlorperazine and Thiopental and the possibility of their joint administration.

Check result:

Prochlorperazine <> Thiopental

Relevance: 13.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited evidence suggests that phenothiazines may increase neuromuscular excitation and hypotension in patients receiving barbiturate anesthetics. The mechanism is unknown. Caution should be exercised if these agents must be used together. Patients should be monitored for altered effects.

References

Dundee JW, Moore J "The effects of premedication with phenothiazine derivatives on the course of methohexitone anaesthesia." Br J Anaesth 33 (1961): 382-96
McMurray TJ, Dundee JW, Henshaw JS "The influence of probenecid on the induction dose of thiopentone." Br J Clin Pharmacol 17 (1984): p224
Dundee JW, Nicholl RM, Moore J "Clinical studies of induction agents. 10: the effect of phenothiazine premedication on thiopentone anaesthesia." Br J Anaesth 36 (1964): 106-9

Prochlorperazine

Generic Name: prochlorperazine

Brand name: Compazine, Compro

Synonyms: n.a.

What is Prochlorperazine?

Thiopental

Generic Name: thiopental

Brand name:

Synonyms: n.a.

What is Thiopental?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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